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Immunoregulatory Cytokines In Rheumatoid Arthritis Patients.
1Morsi MG, 2Shaala AY, 2El-Gerby AH, 1Kandil HW.
1Microbiology Department, Alexandria Faculty of Medicine, 2Internal Medicine Department, Alexandria Faculty of Medicine, Egypt.

The study was designed to estimate the levels of IL-10, TGF-b1 and TNF-a in mitogen stimulated mononuclear cell culture of rheumatoid arthritis (RA) patients in order to find out an association of their altered levels and the disease pathogenesis. Also the effect of IL-10 on TNF-a level was tested in an in vitro cell culture assay. The study included 15 patients with active RA, 15 with inactive RA as well as 15 healthy controls of matched age and sex. Cases were selected on clinical and laboratory bases. The results revealed a highly significant increase in IL-10 level among RA patients (active & inactive ) compared to the controls, also the active cases recorded significantly higher levels than the inactive RA cases. Similarly, TGF-b1 levels were higher in RA patients than the controls, yet the difference was not significant between the active and inactive cases. In spite of the significant higher values of TNF-a observed in the active cases compared to the inactive, the values dramatically diminished after the addition of exogenous IL-10 in the active group. Whereas the decrease in TNF-a level after the addition of exogenous IL-10 in the inactive group was not significant.

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Copyright 2002 Egyptian Association of Immunologists .
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