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| Study of the Interleukin Cascade in Human
Schistosomiasis. |
| 1El Sawy M., 3Loverde P.T., 2Abaza
H., 1Tewfik S., 1Serry K., 1Hassab A.H.,
1Rizk E., 1El-Gendy W. |
| Departments of 1Clinical Pathology, 2Tropical
Medicine, Faculty of Medicine, University of Alexandria, Egypt. 3Department
of Microbiology, Bufflo University, USA. |
Chronic Schistosomiasis mansoni is associated with modulation
and regulation of the host’s immune response leading to the development
of a relatively stable host-parasite relationship. Interleukins play a
central role in the regulation of T-cell - dependent immune responses.
We aimed in this study to estimate the overall production of interleukin
-1 [IL-1] and interleukin –2 [IL-2] production in vitro [using bioassay],
and IL-2 receptor bearing cells in patients with early and late S. mansoni
infection. There was diminished production of IL-1 and IL-2 in all patients,
marked in late cases. IL-2 bearing cells were normal in early cases, but
significantly decreased in late cases. Late cases showed a suppressed specific
and non-specific lympho-proliferative response. Phenotypic quantitation
of T-cells in late S. mansoni cases showed a significant depletion
of CD4 cells.
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