|Study of the Interleukin Cascade in Human
|1El Sawy M., 3Loverde P.T., 2Abaza
H., 1Tewfik S., 1Serry K., 1Hassab A.H.,
1Rizk E., 1El-Gendy W.
|Departments of 1Clinical Pathology, 2Tropical
Medicine, Faculty of Medicine, University of Alexandria, Egypt. 3Department
of Microbiology, Bufflo University, USA.
Chronic Schistosomiasis mansoni is associated with modulation
and regulation of the host’s immune response leading to the development
of a relatively stable host-parasite relationship. Interleukins play a
central role in the regulation of T-cell - dependent immune responses.
We aimed in this study to estimate the overall production of interleukin
-1 [IL-1] and interleukin –2 [IL-2] production in vitro [using bioassay],
and IL-2 receptor bearing cells in patients with early and late S. mansoni
infection. There was diminished production of IL-1 and IL-2 in all patients,
marked in late cases. IL-2 bearing cells were normal in early cases, but
significantly decreased in late cases. Late cases showed a suppressed specific
and non-specific lympho-proliferative response. Phenotypic quantitation
of T-cells in late S. mansoni cases showed a significant depletion
of CD4 cells.