|The Relationship between Pancreatic Beta Cell
Functions and Islets Cell ANtibodies in Insulin Dependent Diabetes Mellitus.
|1Abdel Rahim AA, 2El Guiziry DA and 2El
|1Department of Internal Medicine and 2Department
of Clinical Pathology, Faculty of Medicine, Alexandria University, Egypt.
Serum islet cell antibodies, fasting and postprandial C-peptide were
assayed in 52 subjects with insulin dependent diabetes mellitus and 25
healthy controls. The mean fasting C-peptide was significantly lower in
the diabetic group than the control group. The postprandial C-peptide was
lower in diabetic group II (duration more than two years) than diabetic
group I (duration les than two years). Islet cell antibodies (ICA) were
positive in 65% of patients in group I & 18.7% of patients in group
II. There was a negative correlation between the duration and islet cell
antibodies among group I, whereas there was no significant correlation
among group II. A positive correlation was found between the postprandial
C-peptide and islet cell antibodies among group II but not group I. There
was no correlation detected between islet cell antibodies and the difference
between the fasting and postprandial C-peptide level. This study demonstrates
the presence of ICA in patients with shorter duration of DM and higher
residual beta cell function which suggests its association with ongoing
beta cell destruction. This might be explained by the fact that the pancreatic
islet cells in the newly diagnosed diabetic are antigenic resulting in
the formation of antibodies. The study suggests that positive ICA in some
patients could be indicative of immune interaction.