Human Leukocyte Antigen Subtypes Analysis in Patients With Prostate Cancer.

¹Saad A Noeman, ²Mohamed Ismail Abd El Hamid, ²Afaf Said Zamzam and ³Mohamed Abdel Rehim Hawas.

Departments of ¹Medical Biochemistry, ²Microbiology and ³Urologic Surgery, Faculty of Medicine, University of Tanta, Tanta, Egypt.

A possible association between HLA antigens and prostate cancer was searched for in 15 patients and 300 healthy controls. HLA antigens A25, A26, A28 and B13 were more frequent in patients than in controls. The relative risk for A25, A26, A28 and B13 was 5.78,8.41,4.27, and 5.69, respectively. This increase reached significance before and after correction for the number of antigens tested. As a result, determination of HLA haplotypes may prove useful in determining the males with higher risk of developing prostate cancer.