1Nagwa M Shawky, 1Mohga M Zewar and 2Ali M Saad.
Departments of 1Clinical Pathology and 2Cardiology,
Faculty of Medicine, Zagazig University, Egypt.
The presence of auto-antibodies against oxidized LDL in coronary heart disease patients was estimated to prove that oxidation of LDL is considered an initial step in atherosclerotic process. The study comprised 38 subjects classified into three groups, control group, angina group and myocardial infarction group which was further subdivided into old and acute myocardial infarctions. Results showed no rank correlation between antibody titre to OX-LDL and age, sex, smoking and diabetes mellitus. Also, there was significant increase in the level of auto-antibody to OX-LDL in acute myocardial infarction group when compared with other groups but no significant difference between its level in control group and patients with angina or old myocardial infarction. There was significant increase in the level of total cholesterol and LDL-cholesterol in coronary artery disease patients when compared to control. Also, there was a significant difference in HDL-cholesterol, creatine phospho-kinase (CPK) and LDH levels between the studied groups. CPK and LDH were highly increased in acute myocardial infarction group. There was no significant difference in serum triglycerides level in the studied groups. The present study showed no correlation between OX- LDL antibody and LDL-cholesterol, T. cholesterol and triglycerides. There was a negative correlation between increased level of OX-LDL antibody and decreased level of HDL-cholesterol and there was a positive correlation between OX-LDL antibody and CPK. Also, there was a highly positive correlation between increased level of OX-LDL antibody and that of LDH. The elevated level of antibodies against oxidized LDL was highly increased during acute myocardial infarction and probably plays a critical role in the development and progression of the diseases.