1[†]Seham A Abou Shousha, 2Manal Y Tayel and 1Eman A Rashwan.
1Departments of Immunology, Medical Research Institute, and 2Internal medicine, Faculty of Medicine, Alexandria University, Egypt.
Cellular adhesion molecules have shown an important role in the influx of inflammatory leukocytes into diseased rheumatoid arthritis synovial tissues (RA STs). In this study we have estimated the serum level of soluble intercellular adhesion molecule-1 (sICAM-1) in 17 patients with active RA, 12 patients with active Juvenile chronic arthritis (JCA), 17 patients with osteoarthritis (OA), and 15 normal control volunteers. Our results demonstrated a highly significant elevated levels of sICAM-1 in all the studied patients as compared to the controls. Also, sICAM-1 levels were significantly higher in RA patients than JCA and OA. Meanwhile, no significant difference could be demonstrated between the two later groups. It seems that the role played by sICAM-1 molecules is more prominent in RA than in JCA and OA. Yet, its role in mediating the inflammatory process can not be ignored in the 3 studied groups of patients.
[†] Correspondence: Seham A.
Abou Shousha, Lecturer of Immunology, Medical Research Institute, University of
Alexandria, Alexandria-Egypt.