1Mervat
A Reda, 1Mona LA Zamzam and 2Mervat A Mohamed.
Departments of 1Physical
Medicine and Rehabilitation and 2Microbiology and Immunology,
Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Recent work
has clearly shown that various types of exercise may have potentially
considerable effects, both positive and negative, on immune system. The effect
of 8 weeks exercise training, either on a bicycle or on a treadmill, on the
quantification and phagocytic activity of neutrophils as well as on the serum
levels of cortisol and growth hormone (GH) in non- obese and obese healthy
subjects was studied. Blood samples were obtained from 30 healthy subjects (20
non- obese, 10 obese) before and 8 weeks after exercise training. None of the
studied subjects was under caloric restricted diet during the study. Neutrophil
phagocytic function was assessed by cytomorphological method using Candida
albicans. Serum levels of cortisol and GH were measured using Enzyme
Immunoassay technique. The study revealed a significant increase in the
post-exercise band neutrophil count as well as immature/total neutrophil ratio
compared to pre -exercise values in all studied groups. A significant increase
in the phagocytic index was found after exercise performed by non- obese
subjects, whether bicycle or treadmill, whereas a significant increase in the
opsonic index was found after exercise performed by obese subjects. All studied
groups showed a significant rise in the post-exercise serum level of cortisol
and GH compared to the pre-exercise values. Correlation analysis revealed a
significant negative correlation between the post-exercise serum GH level and
lytic index in non- obese subjects (r = -0.48, P<0.05). A significant positive
correlation was found between the post-exercise GH level and the elevation in
the segmented neutrophil count (r = 0.87, P<0.05), whereas a significant
negative correlation was found between post-exercise serum cortisol level and
the band neutrophil count (r = -0.83, P<0.05) in obese subjects. Obese
persons showed no change in their body weight after 8 weeks exercise training.
It can be concluded that chronic exercise training had a beneficial effect on
the innate immunity represented by increase in both count and phagocytic
function of neutrophils as well as on the levels of neuroendocrine hormones as
cortisol and growth hormone both in obese and non- obese subjects.