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Potential Role of Cytokines in Infection Induced Premature Rupture of Membrane; III- Interleukin One Beta In Premature Rupture of Membranes Whether Term or Preterm.

1Shams AH, 1El-Abd MM, 2Morsi MG and 1Amin MNF.

Departments of 1Obstetrics and Gynaecology and 2Microbiology, Faculty of Medicine, Alexandria University.

The study was conducted upon 75 pregnant women delivering by Caesarean section (CS) route. Group I (n=25) included preterm premature rupture of membranes (PROM) cases (20-37 wks of gestation), Group II (n=25) included full term PROM cases (38-42 wks), Group III (n=25) included the controls who were full term with intact membranes submitted to elective CS. Routine bacteriologic culture, chlamydial LPS and mycoplasmal detection and IL-1b estimation of amniotic fluid samples revealed a significantly elevated IL-1b values among preterm PROM cases with positive bacterial culture compared to negative culture cases. Also full term PROM cases revealed significantly elevated IL-1b values among positive chlamydial amniotic fluid samples. To conclude IL-1b could be a potential marker in infection induced PROM cases. Further studies are warranted to clarify the role of IL-1 receptor antagonist as a causal therapy in PROM cases.