Potential Role of Cytokines in Infection Induced Premature Rupture of Membrane; III- Interleukin One Beta In Premature Rupture of Membranes Whether Term or Preterm.

¹Shams AH, ¹El-Abd MM, ²Morsi MG and ¹Amin MNF.

Departments of ¹Obstetrics and Gynaecology and ²Microbiology, Faculty of Medicine, Alexandria University.

The study was conducted upon 75 pregnant women delivering by Caesarean section (CS) route. Group I (n=25) included preterm premature rupture of membranes (PROM) cases (20-37 wks of gestation), Group II (n=25) included full term PROM cases (38-42 wks), Group III (n=25) included the controls who were full term with intact membranes submitted to elective CS. Routine bacteriologic culture, chlamydial LPS and mycoplasmal detection and IL-1b estimation of amniotic fluid samples revealed a significantly elevated IL-1b values among preterm PROM cases with positive bacterial culture compared to negative culture cases. Also full term PROM cases revealed significantly elevated IL-1b values among positive chlamydial amniotic fluid samples. To conclude IL-1b could be a potential marker in infection induced PROM cases. Further studies are warranted to clarify the role of IL-1 receptor antagonist as a causal therapy in PROM cases.