IL-10 and IL-12p40 in Egyptian Patients with HCV-Related Chronic Liver Disease
1Howayda Hassoba, 1Ola Leheta,
1Amal Sayed, 1Hanaa Fahmy, 1Amal Fathy, 2Faten
Abbas, 3Fawzi Attia,
Departments of 1Clinical
Pathology, 2Physiology, 3Medicine, Suez Canal University, Ismailia Egypt.
Hepatitis C virus (HCV) is the leading cause of chronic liver
disease worldwide with a prevalence of ~14% in Egypt.
IL-10 is a cytokine produced by Th2 cells. It down-regulates the
proinflammatory response and modulates hepatic fibrogenesis.
IL-12 is produced by antigen presenting cells. It promotes Th1 cell response
and has many antiviral properties. Data concerning the Th-1/Th-2 balance in
chronic hepatitis C (CH-C) are rather conflicting. Using ELISA, we assessed serum
IL-10 and IL-12p40 levels in 66 Egyptian patients with HCV-related liver
illness (CH-C, cirrhosis, and HCC), and their relationship to disease activity.
Our results showed that spontaneous IL-10
was undetectable in patients with CH-C, HCC or controls. Only 5/22 (23%) of patients with cirrhosis showed detectable levels of IL-10.
IL-12p40 was elevated in the patient groups compared to controls (p= 0.01, p= 0.01, p= 0.05 in
CH-C, cirrhosis and HCC, respectively). The presence of IL-12p40 was associated
with HCV level of viremia and serum AST. Serum ALT
level was significantly associated with the level of IL-12p40. IL-12p40 was
unrelated to liver histology or fibrosis. We concluded that in the Egyptian
patients an augmentation of IL-12p40 and a suppression of IL-10 are both found.
Whether this pattern is related to HCV genotype 4, or
to the presence of schistosomiasis would need to be