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Serum Procalcitonin As A Marker For Infection In Immune-Mediated Disorders

1Yousry Abdel-Mawla, 2Mahmoud Al-Badry, 3Yousry Abuel-Maged, 4Mahmoud Abdel-Sabour

1Dermatology and Venereology, 2Internal Medicine, 3Biochemistry Departments, Faculty of Medicine; Zagazig university, 4Microbiology and Immunology Department, Faculty of Medicine, Benha university.

The objective of this study was to determine whether or not measuring serum procalcitonin (PCT) level could be a reliable marker for detecting infection during the course of systemic lupus erythematosus (SLE) and guttate psoriasis. Patients with SLE showing evidence of urinary tract infection (16 of 24) of both sexes and within the age group of (19-27) showed a statistically significant (P<0.05) higher serum PCT than in age and sex matched control subjects (n=24) and patients with SLE (with and without disease activity, n=24) without urinary tract infection. Similarly patients with guttate psoriasis manifesting bacterial throat infection (n=20) showed statistically significant (P<0.05) higher serum PCT as compared to the control subjects. In the two groups of patients, antibiotic therapy and cure of infection induced suppression of serum PCT level. Measuring of serum interleukin (IL) 6 among the two groups of patients and controls and assessing serum C-reactive protein (CRP) in control subjects and SLE patients group were also conducted. It is concluded that measuring of serum PCT is helpful in detecting the development of infection during the course of immune-mediated disorders. PCT test is easy and rapid.