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Could Soluble Tumour Necrosis Factor-a Receptor and Soluble Interleukin-2 Receptor Preclude Liver Biopsy for Histologic Grading of Chronic Hepatitis B.?

1Mohammed El-Haggar, 2Attaa Bakr, 3Adel Zalata and 4Khaled Zalata

1Pediatrics, 2Internal Medicine, 3Biochemistry and 4Pathology Departments, Faculty of Medicine, Mansoura University.


The aim of the present study was to evaluate the role of soluble interleukin 2 receptor (sIL2R) and soluble tumor necrosis factor a receptor (sTNFaR) in patients with chronic hepatitis B in assessment of the severity of the disease. Sixty-three patients with different stages of chronic hepatitis B were investigated. Serum sIL2R and sTNFaR were determined by ELISA and compared with those of 20 healthy normal controls. The levels of sIL-2R and sTNFaR were significantly higher in the diseased group (P< 0.001). In addition, these markers showed linear increase in relation to the severity of the disease, and was more obvious with sTNFaR than IL-2R.. Liver function tests as well as sTNFaR were correlated with liver biopsy by means of discriminant analysis. Soluble TNFaR was found to be a better predictor for the histologic staging of chronic hepatitis B. It is concluded that, sTNFaR together with some liver function tests could be used as a predictor for the histologic progress of chronic hepatitis B.